Fiber-seq is already being applied in a variety of research areas, from human genetics to plant biology. These studies showcase how the assay can reveal chromatin structure and regulatory mechanisms that are inaccessible to short-read methods.
Examples from published research:
Human disease: Linking structural variants to disrupted regulatory elements — Vollger et al., 2025 (PMID: 39880924)
Neuroepigenomics: Nucleosome mapping and TF footprinting in brain — Peter et al., 2024 (PMID: 39631398)
Immune regulation: Haplotype-specific accessibility at HLA loci — Vollger et al., 2025 (PMID: 40501892) (bioRxiv preprint)
Plant epigenomics: Mapping repetitive elements in maize — Bubb et al., 2025 (PMID: 40360747)
3D genome structure: Predicting haplotype-specific organization with deep learning — Dubocanin et al., 2025 (bioRxiv preprint)