---
title: "What sample types are compatible with the CUTANA™ ATAC-seq Kit?"
slug: "what-sample-types-are-compatible-with-the-cutana-atac-seq-kit"
status: "new"
updated: 2026-09-15T01:27:16Z
published: 2026-09-15T01:27:16Z
canonical: "support.epicypher.com/what-sample-types-are-compatible-with-the-cutana-atac-seq-kit"
---

> ## Documentation Index
> Fetch the complete documentation index at: https://support.epicypher.com/llms.txt
> Use this file to discover all available pages before exploring further.

# What sample types are compatible with the CUTANA™ ATAC-seq Kit?

The CUTANA™ ATAC-seq kit is compatible with eukaryotic cells (including fresh, cryopreserved, adherent, and suspension) and flash-frozen tissues (including freshly extracted and cryopreserved nuclei). If using cryopreserved nuclei as starting material, skip cell harvest and nuclei extraction steps (steps 6-15 of Section II: Nuclei Extraction) in manual.

Notes:

- Sample quality and nuclei preparation can influence experimental success. Refer to [this article](https://support.epicypher.com/docs/how-do-i-confirm-high-quality-sample-preparation-for-atac-seq) for guidance on assessing nuclei quality before tagmentation.
- Tissue dissociation and nuclei isolation may require sample-specific optimization upstream of the ATAC-seq workflow. For general guidelines on processing tissues for nuclei extraction, see this [article](https://support.epicypher.com/docs/what-are-general-guidelines-for-processing-tissue-for-cutana-assays).