---
title: "What are the real-world applications of Fiber-seq?"
slug: "what-are-the-real-world-applications-of-fiber-seq"
updated: 2025-09-24T15:15:26Z
published: 2025-11-11T13:00:01Z
canonical: "support.epicypher.com/what-are-the-real-world-applications-of-fiber-seq"
---

> ## Documentation Index
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# What are the real-world applications of Fiber-seq?

Fiber-seq is already being applied in a variety of research areas, from human genetics to plant biology. These studies showcase how the assay can reveal chromatin structure and regulatory mechanisms that are inaccessible to short-read methods.

**Examples from published research:**

- **Human disease:** Linking structural variants to disrupted regulatory elements — [Vollger et al., 2025](https://www.nature.com/articles/s41588-024-02067-0) (PMID: 39880924)
- **Neuroepigenomics:** Nucleosome mapping and TF footprinting in brain — [Peter et al., 2024](https://www.cell.com/cell-reports-methods/fulltext/S2667-2375(24)00301-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2667237524003011%3Fshowall%3Dtrue) (PMID: 39631398)
- **Immune regulation:** Haplotype-specific accessibility at HLA loci — [Vollger et al., 2025](https://www.biorxiv.org/content/10.1101/2024.06.14.599122v2) (PMID: 40501892) (bioRxiv preprint)
- **Plant epigenomics:** Mapping repetitive elements in maize — [Bubb et al., 2025](https://www.nature.com/articles/s41477-025-02002-z) (PMID: 40360747)
- **3D genome structure:** Predicting haplotype-specific organization with deep learning — [Dubocanin et al., 2025](https://www.biorxiv.org/content/10.1101/2025.02.26.640261v2.full) (bioRxiv preprint)