---
title: "CUTANA™ CUT&RUN Protocol | Step-by-Step Chromatin Profiling Guide"
slug: "cutana-cut-and-run-protocol"
description: "Follow the CUTANA™ CUT&RUN protocol with step-by-step instructions for chromatin profiling, from sample prep to sequencing-ready DNA."
updated: 2026-09-23T21:50:24Z
published: 2026-09-23T21:50:24Z
canonical: "support.epicypher.com/cutana-cut-and-run-protocol"
---

> ## Documentation Index
> Fetch the complete documentation index at: https://support.epicypher.com/llms.txt
> Use this file to discover all available pages before exploring further.

# Where can I find the CUTANA™ CUT&RUN Protocol?

If you are using the CUTANA CUT&RUN Kit ([EpiCypher 14-1048](https://www.epicypher.com/products/epigenetics-reagents-and-assays/cutana-chic-cut-and-run-kit)), please use the [kit manual](https://www.epicypher.com/resources/protocols/cutana-cut-and-run-kit-manual).

If you are performing CUT&RUN with the standalone CUTANA pAG-MNase ([EpiCypher 15-1016/15-1116](https://www.epicypher.com/products/epigenetics-reagents-and-assays/cutana-pag-mnase-for-chic-cut-and-run-workflows)) and homemade buffers, please follow the current version of the [CUTANA CUT&RUN DIY Protocol](https://support.epicypher.com/docs/cutrun-diy-protocol).