---
title: "Can I use my ChIP antibody for CUTANA™ assays?"
slug: "can-i-use-my-chip-antibody-for-cutana-assays"
description: "Learn whether ChIP-validated antibodies work in CUTANA™ assays, why validation differs, and how to choose antibodies for best results."
tags: ["cut and run"]
updated: 2026-02-27T15:25:19Z
published: 2026-02-27T15:25:19Z
canonical: "support.epicypher.com/can-i-use-my-chip-antibody-for-cutana-assays"
---

> ## Documentation Index
> Fetch the complete documentation index at: https://support.epicypher.com/llms.txt
> Use this file to discover all available pages before exploring further.

# Can I use my ChIP antibody for CUTANA™ assays?

> This article also applies to Multiomic CUT&RUN.

You may try using ChIP antibodies for CUTANA™ assays, but fair warning: EpiCypher has found that success in ChIP does **NOT** guarantee success in CUT&RUN, CUT&Tag, or related chromatin mapping assays.

This is largely due to differences in sample prep and processing steps ([see this blog](https://www.epicypher.com/resources/blog/chipseq-vs-cutrun-vs-cuttag-which-should-you-use/) for information). ChIP uses heavily cross-linked cells, stringent wash buffers, and bead-coupled antibodies to help maximize the signal-to-noise ratio. However, these strategies often lead to loss of on-target signal, which is particularly problematic for low abundance targets. To counteract these effect, ChIP requires highly efficient antibodies, with high yields.

In contrast, CUT&RUN uses native chromatin, mild washes, and antibodies in solution, reflecting the increased sensitivity of this newer technique. The only way to know if your antibody will work in CUTANA assays if the antibody has been tested in this assay - antibody validation using ChIP, immunoblot, ELISA, IHC, or other techniques is **NOT** a predictor of CUTANA performance.

For your convenience, EpiCypher offers CUT&RUN- and CUT&Tag-validated antibodies, which you can shop [here](https://www.epicypher.com/antibodies-complete-list/).